In Vivo Clastogenicity of Chromate in Mice Lead

WATANABE, M., TAKAYAMA, Y., KOIKE, M. and YAMAMOTO, M. In Vivo Clastogenicity of Lead Chromate in Mice. Tohoku J. exp. Med., 1985, 146 (3), 373-374 Cytogenetical effects of lead chromate were evaluated in vivo. When 0.5, 1, 2 and 4 g/kg body weight of lead chromate suspensions in 0.5% gum arabic were administered i.p. to C57BL/6N male mice twice, the frequencies of micronucleated polychromatic erythrocytes in the femoral bone marrow were significantly (p <0.01) different from that in the vehicle control. Moreover, as the dose increased, the ratio of the polychromatic to normochromatic erythrocytes decreased in a dose-response fashion (p <0.05). Thus, it is concluded that lead chromate in vivo gives rise to chromosomal damage as well as disturbance in hematopoiesis. lead chromate ; chromosomal damage ; micronucleus test ; in vivo clastogenicity ; hematopoiesis